Serological screening of immunoglobulin M and immunoglobulin G during pregnancy for predicting congenital cytomegalovirus infection
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چکیده
منابع مشابه
PREPARATION OF ENRICHED IMMUNOGLOBULIN M AND IMMUNOGLOBULIN A FROM HUMAN PLASMA
As IgM and IgA-enriched preparations are needed to complete the immunotherapeutic spectrum, a simple procedure is described for the preparation of IgM and IgA enriched immunoglobulins. Fraction III which was prepared by cold ethanol fractionation was treated by octanoic acid followed by ethanol precipitation and ion-exchange chromatography using Sephadex DEAE A-50 and 0.1 M tris-D.35M NaCI ...
متن کاملPassive immunization during pregnancy for congenital cytomegalovirus infection.
BACKGROUND Currently, there is no effective intervention for a primary cytomegalovirus (CMV) infection during pregnancy. METHODS We studied pregnant women with a primary CMV infection. The therapy group comprised women whose amniotic fluid contained either CMV or CMV DNA and who were offered intravenous CMV hyperimmune globulin at a dose of 200 U per kilogram of maternal weight. A prevention ...
متن کاملPassive Immunization During Pregnancy for Congenital Cytomegalovirus Infection
REVIEWER COMMENTS. Vaccine strategies taking into account the enormous variability at the genomic and proteomic levels that many pathogens have evolved are the best hedge against a mere “arms race” in which temporary vaccine efficacy gives way to the emergence of antigenic variants. This is a novel application of such a rational strategy. However, the extent of the challenge is underscored by t...
متن کاملScreening for Cytomegalovirus during Pregnancy
The epidemiology and pathogenesis of CMV infections among pregnant women have been intensely studied over the last three decades. This paper highlights recent developments that make either universal or limited serologic screening for CMV during pregnancy potentially attractive. The developments include an understanding of the pathogenesis of CMV infections, a knowledge of high-risk women, the a...
متن کاملSerological studies in asymptomatic congenital cytomegalovirus infection.
Immunological abnormalities have been described in patients with cytomegalovirus mononucleosis or with post-perfusion syndrome due to cytomegalovirus (CMV) (Wager et al., 1968; Klemola et al., 1969; Kantor et al., 1970). These abnormalities include the development of cryoglobulinaemia, elevation or depression of serum immunoglobulin levels, and the appearance of humoral autoantibodies, includin...
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ژورنال
عنوان ژورنال: BMC Pregnancy and Childbirth
سال: 2019
ISSN: 1471-2393
DOI: 10.1186/s12884-019-2360-1